Novel implant and novel vector for the treatment of acquired...

Details Novel implant and novel vector for the treatment of acquired... Novel implant and novel vector for the treatment of acquired...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 9/00 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C07K 16/10 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2199715

Genetically modified cell implant comprising an exogenous nucleotide sequence coding for all or part of an antibody, method for the preparation of such an implant and its therapeutic use for the treatment or prevention of an acquired disease. The invention also concerns an adenoviral vector for the expression of one or more proteins capable of forming a multimer, viral particles and cells containing the adenoviral vector, a pharmaceutical composition and its therapeutic use.

La présente invention concerne un implant de cellules génétiquement modifiées comprenant une séquence nucléotidique exogène codant pour tout ou partie d'un anticorps. Elle couvre également une méthode de préparation d'un tel implant ainsi que son utilisation thérapeutique pour le traitement ou la prévention d'une maladie acquise. Elle a également pour objet un vecteur adénoviral pour l'expression d'une ou plusieurs protéine(s) capable(s) de former un multimère, les particules virales et les cellules le contenant ainsi qu'une composition pharmaceutique et son utilisation thérapeutique.

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