Rat cathepsin k polynucleotide & polypeptide sequence

Details Rat cathepsin k polynucleotide & polypeptide sequence Rat cathepsin k polynucleotide & polypeptide sequence

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/55 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2225174

rat cathepsin k polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rat cathepsin k polypeptides and polynucleotides in the design of protocols for the treatment of osteoporosis, periodonatal disease, arthritis, cancer, tumor metastasis, and Paget's disease, among others, and diagnostic assays for such conditions.

On divulgue des polypeptides et polynucléotides de cathepsine k de rat et des méthodes pour produire ces polypeptides par les techniques de recombinaison. On divulgue également des méthodes pour utiliser les polypeptides et polynucléotides de cathepsine k de rat dans la conception de protocoles pour le traitement de l'ostéoporose, de la parodontopathie, de l'arthrite, du cancer, des métastases tumorales, et de la maladie osseuse de Paget, entre autres, et les épreuves diagnostiques pour ces affections.

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