Controlling growth of filamentous microorganisms

C - Chemistry – Metallurgy – 12 – N

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C12N 1/14 (2006.01)

Patent

CA 2125648

A process for the cultivation in continuous culture of a filamentous microorganism in a culture medium to which are sup- plied sources of carbon and other appropriate nutrients. The carbon or another nutrient source is supplied in an amount limiting to the growth of the culture and constitutes a limiting nutrient thereto. The development of an unwanted variant of the filamen- tous microorganism is restricted or delayed by supplying a first nutrient source to the culture as a limiting nutrient, and thus changing the nutrient supply to the culture in a manner such that a second nutrient source replaces the first nutrient source as the limiting nutrient:

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