New therapy and medicament using integrin ligands for...

A - Human Necessities – 61 – K

Patent

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A61K 38/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2744134

The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.

L'invention concerne une thérapie de combinaison, pour le traitement de tumeurs et de métastases de tumeur, qui comporte l'administration de ligands d'intégrine, de préférence d'antagonistes d'intégrine, conjointement avec des agents co-thérapeutiques ou des formes de thérapie qui ont une efficacité synergique lorsqu'elles sont administrées consécutivement auxdits ligands, tels que des agents chimiothérapiques et/ou une radiothérapie. La thérapie conduit à une augmentation du potentiel synergique de l'effet inhibiteur de chaque produit thérapeutique individuel sur la prolifération de cellules tumorales, permettant dobtenir un traitement plus efficace que celui obtenu par l'administration d'un composant individuel seul, simultanément ou non dans le schéma de posologie de la présente invention.

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