Tissue engineered stents

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/14 (2006.01) A61F 2/82 (2006.01) A61L 27/58 (2006.01) A61L 27/38 (2006.01) C12N 5/06 (2006.01) A61F 2/02 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2407612

This invention is directed to a tissue-engineered stent comprising a substantially cylindrical construct (10) having a first end (12) and a second end (14); a walled surface (16) disposed between the first end and the second end; the walled surface (16) comprising a biodegradable polymer scaffold seeded with disassociated chondrocytes. In one embodiment, the seeded scaffold is cultured in vitro prior to implantation in a host for a time period sufficient for cartilaginous tissue to form.

La présente invention concerne un tuteur mis au point grâce au génie tissulaire comportant une construction sensiblement cylindrique (10) présentant une première extrémité (12) et une deuxième extrémité (14) ; une surface enfermée (16) disposée entre la première extrémité et la deuxième extrémité, la surface enfermée (16) comprenant une charpente en polymère biodégradable ensemencé de chondrocytes dissociés. Dans un mode de réalisation, la charpente ensemencée est cultivée in vitro préalablement à l'implantation dans un hôte pendant une période suffisante pour permettre la formation de tissu cartilagineux.

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