Antiviral therapy use of p-glycoprotein modulators

Details Antiviral therapy use of p-glycoprotein modulators Antiviral therapy use of p-glycoprotein modulators

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/195 (2006.01) A61K 31/20 (2006.01) A61K 31/205 (2006.01) A61K 31/22 (2006.01) A61K 31/24 (2006.01) A61K 31/34 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/50 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2378984

The present invention relates to a pharmaceutical composition comprising a 10, 11 methanodibenzosuberane and use thereof for the treatment of HIV infection. Co-administration of the 10, 11 methanodibenzosuberane with an HIV protease inhibitor increases the concentration of the protease inhibitor in certain tissues, including the brain and testes, without substantially increasing plasma levels of the protease inhibitor. Accordingly, additional antiviral therapy can be achieved without use of increased drug dosages, thereby reducing the potential for occurrence of undesirable side effects deriving from drug toxicity.

L'invention concerne une composition pharmaceutique comprenant un 10, 11 méthanodibenzosubérane, et l'utilisation de cette composition pour le traitement de l'infection à VIH. L'administration conjointe de ce 10, 11 méthanodibenzosubérane et d'un inhibiteur de protéase VIH permet d'augmenter la concentration de l'inhibiteur de protéase dans certains tissus, notamment dans le cerveau et dans les testicules, sans augmenter de manière notable les concentrations plasmiques de l'inhibiteur de protéase. On peut ainsi mettre en oeuvre un traitement antiviral complémentaire sans augmentation des dosages des médicaments, ce qui permet de réduire le risque d'effets secondaires liés à la toxicité des médicaments.

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