Tetronic and tetramic acids as inhibitors of beta-secrease

Details Tetronic and tetramic acids as inhibitors of beta-secrease Tetronic and tetramic acids as inhibitors of beta-secrease

C - Chemistry, Metallurgy

07

D

C07D 307/60 (2006.01) C07D 207/38 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01) C07D 495/06 (2006.01)

Patent

CA 2545294

This invention relates to new tetronic and tetramic acid derivatives with beta- secretase inhibitory activity of formula (I), wherein RI, R2, R3, R4, R5, R5', R6 and R6' areas defined hereinabove, to processes for their preparation, compositions containing said tetronic and tetramic acid derivatives and their use in the treatment and prevention of diseases modulated by an inhibitor of .szlig.-secretase, such as Alzheimer's disease.

L'invention concerne des nouveaux dérivés d'acide tétronique et tétramique présentant une activité inhibitrice de la .szlig.-sécrétase de formule générale (I), dans laquelle RI, R2, R3, R4, R5, R5', R6 et R6' ont la signification indiquée dans la description, des procédés de préparation associés, des compositions les contenant et leur utilisation dans le traitement et la prévention de maladies modulées par un inhibiteur de la .szlig.-sécrétase, de type maladie d'Alzheimer.

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