A process for the preparation of 1-(aminomethyl)...

Details A process for the preparation of 1-(aminomethyl)... A process for the preparation of 1-(aminomethyl)...

C - Chemistry, Metallurgy

07

C

C07C 227/42 (2006.01) C07C 227/18 (2006.01) C07C 229/28 (2006.01)

Patent

CA 2436908

A conversion process of gabapentin hydrochloride into gabapentin comprising: a) dissolution of gabapentin hydrochloride in a solvent in which the gabapentin hydrochloride and the gabapentin are completely soluble; and b) subsequent addition of an amine that allows the removal of the chloride ion from the solution containing gabapentin hydrochloride, by precipitation of the hydrochloride of the same amine, leaving the gabapentin in solution in free amino acid form.

L'invention concerne un procédé de conversion d'hydrochlorure de gabapentine en gabapentine comprenant: a) la dissolution d'hydrochlorure de gabapentine dans un solvant dans lequel l'hydrochlorure de gabapentine et le gabapentine sont complètement solubles; et b) l'adjonction subséquente d'un amine permettant de retirer les ions chlorure contenant l'hydrochlorure de gabapentine, par précipitation de l'hydrochlorure du même amine, en laissant le gabapentine en solution sous forme d'aminoacide libre.

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