Treatment and diagnosis of infections of gram positive cocci

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/40 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/085 (2006.01) C07K 7/06 (2006.01) C07K 14/195 (2006.01) C07K 14/31 (2006.01) C07K 16/12 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2259141

The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralising agents specific thereto and binding agents specific thereto for therapeutic and diagnostic use, together with diagnostic test methods, methods of same and kits for performing same. Also provided are immunodominant conserved antigens from gram positive staphylococci, together with neutralising and binding agents specific thereto for use in therapy and diagnosis, and methods of same. Also provided are Staphylococcal holomogues of IstA and IstB and immunogenic fragments thereof, and their uses in methods of treatment and diagnosis of the human or animal body.

L'invention concerne des protéines de transport ABC bactériennes et fongiques, des fragments immunogènes de ces protéines, des agents neutralisants et des agents de liaison leur étant spécifiques pour un usage thérapeutique et diagnostique, ainsi que des méthodes de test diagnostiques, des méthodes et matériels pour leur application. L'invention porte également sur des antigènes immunodominants conservés de staphylocoques gram positif, ainsi que sur des agents de neutralisation et de liaison spécifiques à ces antigènes utilisables dans les traitements et les diagnostics, et des méthodes d'utilisation. Sont également décrits des homologues staphylocociques de IstA et IstB, des fragments immunogènes de ces derniers et leur utilisation dans des méthodes de traitement et de diagnostic s'appliquant au corps humain ou animal.

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