Oxamic acids and derivatives as thyroid receptor ligands

Details Oxamic acids and derivatives as thyroid receptor ligands Oxamic acids and derivatives as thyroid receptor ligands

C - Chemistry, Metallurgy

07

C

C07C 323/41 (2006.01) A61K 31/10 (2006.01) A61K 31/165 (2006.01) A61P 5/16 (2006.01) C07C 235/74 (2006.01) C07C 311/29 (2006.01) C07C 317/22 (2006.01) C07C 317/50 (2006.01) C07D 209/08 (2006.01) C07D 211/14 (2006.01) C07D 211/16 (2006.01) C07D 215/08 (2006.01) C07D 215/20 (2006.01) C07D 217/04 (2006.01) C07D 217/06 (2006.01) C07D 217/08 (2006.01) C07D 295/096 (2006.01) C07D 295/192 (2006.01) C07D 295/26 (2006.01) C07D 317/58 (2006.01) C07D 333/20 (2006.01)

Patent

CA 2363145

The present invention provides novel compounds of Formula (I) and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R1-R8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, glaucoma, cardiac arrythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.

L'invention concerne des nouveaux composés de formule (I) et des promédicaments, des isomères géométriques et optiques de ces derniers, ainsi que des sels desdits composés, promédicaments et isomères, acceptables au plan pharmaceutique,, R<1>-R<8> et W étant décrits dans le dossier. L'invention porte également sur des compositions pharmaceutiques contenant lesdits composés, sur des promédicaments, des isomères ou des sels de ceux-ci, acceptables au plan pharmaceutique, ainsi que sur des kits pour le traitement de l'obésité, de l'hyperlipidémie, du glaucome, de l'arrhytmie cardiaque, de troubles dermatologiques, de la maladie thyroïdienne, de l'hypothyroïdie et de troubles associés, ainsi que des maladies, telles que le diabète sucré, l'athérosclérose, l'hypertension, la maladie coronarienne, l'hypercholestérolémie, la dépression et l'ostéoporose.

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