Anthranilic acid amides with a heteroarylsulfonyl side...

Details Anthranilic acid amides with a heteroarylsulfonyl side... Anthranilic acid amides with a heteroarylsulfonyl side...

C - Chemistry, Metallurgy

07

D

C07D 215/36 (2006.01) A61K 31/33 (2006.01) A61K 31/47 (2006.01) A61K 45/06 (2006.01) A61P 9/06 (2006.01) C07D 213/71 (2006.01) C07D 217/02 (2006.01) C07D 261/10 (2006.01) C07D 271/12 (2006.01) C07D 333/34 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2450076

The invention relates to compounds of formula (I), wherein R(1) -R(7) have the meanings cited in the claims. Said compounds act upon the Kv1.5-potassium channel and inhibit a potassium flow in the atrium of the human heart, designated as an ultra-rapidly activating delayed rectifier. As a result, they are particularly suitable for use as novel antiarrhythmic active substances, especially in the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.

L'invention concerne les composés de la formule (I) dans laquelle R(1) à R(7) ont la signification donnée dans les revendications. Les composés selon l'invention agissent sur le canal de potassium Kv1.5 et inhibent un flux de potassium appelé <= rectificateur retardé d'activation ultra-rapide >= dans l'oreillette. Ainsi, lesdits composés servent notamment de nouveaux agents actifs anti-arythmisants, en particulier pour le traitement et la prophylaxie d'arythmies auriculaires, par ex. de la fibrillation auriculaire ou du flutter auriculaire.

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