Therapeutic uses of monoclonal antibodies to the...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/22 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2496422

The use of monoclonal antibodies to the angiotensin-II type-I receptor is provided for the treatment of cancer and vascular smooth muscle cell proliferation. Specifically, use is provided of a monoclonal antibody or a fragment thereof to a peptide comprising the N-terminal portion of the angiotensin-II type-1 receptor defined by the sequence MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFG in the preparation of a medicament for the treatment of cancer or in the preparation of a medicament for the treatment of vascular smooth muscle (VSM) cell proliferation.

L'invention concerne l'utilisation d'anticorps monoclonaux contre le récepteur d'angiotensine-II de type-I dans le traitement du cancer et de la prolifération cellulaire du muscle lisse vasculaire. En particulier, l'invention concerne l'utilisation d'un anticorps monoclonal ou d'un fragment de cet anticorps contre un peptide comprenant la partie N-terminal du récepteur d'angiotensine-II de type 1 définie par la séquence MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFG dans la préparation d'un médicament pour le traitement du cancer ou dans la préparation d'un médicament pour le traitement de la prolifération cellulaire du muscle lisse vasculaire (VSM).

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