Subcutaneous implants containing a degradation-resistant...

Details Subcutaneous implants containing a degradation-resistant... Subcutaneous implants containing a degradation-resistant...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 38/09 (2006.01)

Patent

CA 2642759

The present invention refers to compositions comprising a LH-RH-analogue and/or pharmaceutically acceptable salts thereof in a low-dose and a degradation-resistant polylactide suitable for the preparation of subcutaneous implants. Sterilisation of the polylactide via gamma-radiation as well as temperature stress result in a negligible decomposition of less than 1000 Dalton.

La présente invention concerne des compositions contenant un analogue de la LH-RH et/ou des sels pharmaceutiquement acceptables de cet analogue, à faible dose et un polylactide résistant à la dégradation permettant la préparation d'implants sous-cutanés. La stérilisation du polylactide par un rayonnement gamma ainsi que la contrainte thermique conduisent à une décomposition négligeable inférieure à 1000 Dalton.

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