Chimaeric proteins between members of tgf-beta superfamily

Details Chimaeric proteins between members of tgf-beta superfamily Chimaeric proteins between members of tgf-beta superfamily

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2344974

The invention provides modified proteins and DNAs of the TGF-.beta. superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through substitutions of amino acids in the finger 2 sub-domain or exchanges of all or part of the finger 2 sub-domain of one TGF-.beta. superfamily member with the finger 2 sub-domain of another TGF-.beta. superfamily member.

La présente invention concerne des ADN et des protéines modifiées de la superfamille du TGF-.beta., notamment des protéines morphogéniques modifiées. Les protéines de cette invention présentent des attributs biologiques ou biochimiques modifiés. Plus particulièrement, ces protéines modifiées sont élaborées en substituant des amino-acides dans le sous-domaine du doigt 2, ou en échangeant le sous-domaine du doigt 2 d'un membre de la superfamille du TGF-.beta. dans sa totalité ou en partie, par le sous-domaine du doigt 2 d'un autre membre de la superfamille des TGF-.beta..

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