Molecular clones producing recombinant dna antigens of the...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/40 (2006.01) A61K 39/12 (2006.01) C07K 14/175 (2006.01) C07K 16/10 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2168030

The invention provides HARDS virus rDNA for expression in molecular clones. The expressed products are useful in immunodiagnostics, prophylactics, and therapeutics for the HARDS virus and related hantaviruses. Of particular interest are a type- specific epitope of the HARDS virus G1 protein, and dominant epitopes of the HARDS virus N protein cross-reactive with antibodies to the HARDS virus and the related hantavirus PHV, both expressed by cDNA clones according to the invention.

L'invention se rapporte à l'ADNr du virus de HARDS (syndrome de détresse respiratoire associé à l'hantavirus) destiné à être exprimé dans des clones moléculaires. Les produits exprimés sont utilisés dans le diagnostic immunologique, la prophylaxie et la thérapie du virus de HARDS et des hantavirus apparentés. L'épitope à spécificité de type de la protéine G1 du virus de HARDS ainsi que les épitopes dominants de la protéine N du virus de HARDS présentant une réaction croisée avec des anticorps dirigés contre le virus de HARDS et l'hantavirus PHV apparenté ont été particulièrement étudiés et sont exprimés par les clones de l'ADNc de l'invention.

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