A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 31/04 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)
Patent
CA 2729646
Controlled release vascular implants, such as vascular grafts, stents, wraps, and gels comprising a biocompatible polymer and all trans retinoic acid (ATRA), or its derivatives, can be used to treat, prevent, or inhibit thrombosis and/or neointimal hyperplasia which may otherwise be induced by prosthetic implantation. In particular, the implants herein can inhibit smooth muscle cell proliferation, neointimal hyperplasia, and upregulate antithrombotic genes and nitric oxide production in the vasculature. Further, the implants are capable of delivering controlled and predictable localized concentrations of ATRA.
Des implants vasculaires à libération contrôlée, tels que des greffes vasculaires, des stents, des enveloppes vasculaires, et des gels comprenant un polymère biocompatible ainsi quun acide tout trans rétinoïque (ATRA), ou ses dérivés, peuvent être utilisés pour traiter, prévenir, ou inhiber une thrombose et/ou une hyperplasie néointimale qui peuvent autrement être induites par limplantation dune prothèse. Les implants de la présente invention peuvent notamment inhiber la prolifération des cellules des muscles lisses, lhyperplasie néointimale, et réguler à la hausse les gènes antithrombotiques et la production doxyde nitrique dans le système vasculaire. Les implants sont en outre capables de délivrer des concentrations localisées et prévisibles dATRA.
Ameer Guillermo A.
Kibbe Melina
Webb Antonio
Smart & Biggar
Vesseltek Biomedical Llc
LandOfFree
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