Methods for reducing immunogenicity of polypeptides

Details Methods for reducing immunogenicity of polypeptides Methods for reducing immunogenicity of polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/02 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) C07K 1/00 (2006.01) C07K 1/107 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 9/64 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2453406

This invention relates to the fields of immunology and protein therapeutics. The therapeutic proteins are polypeptides to be administered especially to humans. The polypeptides are modified whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention therefor provides methods for the development of therapeutic polypeptides that are less immunogenic than any non-modified counterpart when used in vivo. The modifications used according to this invention relate, for example, to the introduction of protease cleavage sites, attachment of different molecules or insertion of non- natural amino acids.

La présente invention à trait au domaine de l'immunologie et de thérapeutique aux protéines. Les protéines thérapeutiques sont des polypeptides à être administrés notamment aux humains. Les polypeptides sont modifiés de sorte que le polypeptide présente une propension réduite à déclencher une réponse immunitaire lors de son administration à un sujet humain. A cet effet, l'invention propose des procédés pour le développement de polypeptides thérapeutiques qui sont moins immunogènes que leurs analogues non modifiés lors de leur utilisation in vivo. Les modification mises en oeuvre selon l'invention ont trait, par exemple, à l'insertion de sites de clivage de la protéase, la fixation de diverses molécules ou l'insertion d'acides aminés synthétiques.

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