C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 39/395 (2006.01) B01D 15/08 (2006.01) C07H 21/00 (2006.01) C07K 17/10 (2006.01) C12N 9/64 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2088222
ABSTRACT The present invention relates to pro-hormone convertases and polypeptidic fragments thereof, nucleic acids encoding them, recombinant viruses expressing these convertases, polyclonal antibodies directed against the convertases, diagnostic kits for the detection and measurement of the convertase content in cell or tissue lysates, culture media or biological fluids by RIA. Diagnostic kits were also developped for detection or measurement of nucleic acids, preferably mRNAs, in cell or tissue lysates by hybridization. The invention also concerns oligonucleotides useful as probes or as primers for DNA synthesis. These oligonucleotides were included in the diagnostic kits as well as used for the obtention of specific fragments of the convertases which have served, together with native convertases, as antigens for the obtention of antibodies. The convertases were produced by mammalian cell lines transfected with the recombinant viruses and purified on affinity columns which are also an object of the invention. Processes for producing the native convertases, fragments thereof and antibodies are also described and claimed.
Chretien Michel
Seidah Nabil G.
Clinical Research Institute Of Montreal
Goudreau Gage Dubuc
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