Cyclohexylglycine derivatives as dipeptidyl peptidase...

Details Cyclohexylglycine derivatives as dipeptidyl peptidase... Cyclohexylglycine derivatives as dipeptidyl peptidase...

C - Chemistry, Metallurgy

07

D

C07D 277/68 (2006.01) A61K 31/428 (2006.01)

Patent

CA 2527806

The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.

La présente invention concerne de nouveaux dérivés de cyclohexylglycine qui sont des inhibiteurs d'enzyme dipeptidyl peptidase IV ("inhibiteurs de DP-IV") et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles l'enzyme dipeptidyl peptidase IV est impliquée, telles que le diabète et notamment le diabète de type 2. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés et l'utilisation desdits composés et desdites compositions dans la prévention ou le traitement desdites maladies dans lesquelles l'enzyme dipeptidyl peptidase IV est impliquée.

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