Dihydro pyrazolopyrroles

Details Dihydro pyrazolopyrroles Dihydro pyrazolopyrroles

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2181175

The compounds of formula (I) and the pharmaceutically acceptable salts thereof; whrein X1, R1, R2, R3 and R4 are as defined herein, are inhibitors of PDE IV andthe production of tumor necrosis factor. As such, they are active in the treatment of inflammatory diseases, shock, etc.

Composés de la formule (I), et leurs sels pharmaceutiquement acceptables; formule dans laquelle X¿1?, R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que définis dans le descriptif. Ces composés sont des inhibiteurs de phosphodiestérase de type IV (PDE IV) ainsi que de la production du facteur de nécrose des tumeurs. En tant que tels, ils sont des agents actifs dans le traitement des maladies inflammatoires, du choc septique, etc.

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