Clear, chemically modified collagen-synthetic polymer...

Details Clear, chemically modified collagen-synthetic polymer... Clear, chemically modified collagen-synthetic polymer...

C - Chemistry, Metallurgy

07

K

C07K 14/78 (2006.01) A61F 2/14 (2006.01) A61K 47/48 (2006.01) A61L 24/10 (2006.01) A61L 27/00 (2006.01) A61L 27/24 (2006.01) A61L 31/04 (2006.01) C07K 17/08 (2006.01) C08H 1/06 (2006.01) C09J 189/06 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2134744

CLEAR. CHEMICALLY MODIFIED COLLAGEN-SYNTHETIC POLYMER CONJUGATES FOR OPHTHALMIC APPLICATIONS Abstract of the Disclosure Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in substantially nonfibrillar form at pH 7 and is preferably succinylated or methylated collagen. The synthetic hydrophilic polymer is preferably an activated polymeric glycol, most preferably, a di- or multifunctionally activated polyethylene glycol. Materials and devices formed with the chemically modified collagen-synthetic polymer conjugates have good optical clarity, mechanical strength, and moldability. 38

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