Phenyl-substituted alkenylcarboguanidides carrying...

Details Phenyl-substituted alkenylcarboguanidides carrying... Phenyl-substituted alkenylcarboguanidides carrying...

C - Chemistry, Metallurgy

07

C

C07C 279/22 (2006.01) A01N 1/02 (2006.01) A61K 31/165 (2006.01)

Patent

CA 2152137

Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, of the formula I (see Formula I) in which the substituents have the meanings stated in the description, and their pharmaceutically suitable salts, are described. They are obtained by reacting a compound II (see Formula II) with guanidine, in which R(1) to R(5) and R(A), R(B), R(C) and R(D) have the stated meaning, and L is a leaving group which easily undergoes nucleophilic substitution. Compounds I are excellent cardiovascular therapeutic agents.

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