Substituted 2-phenylaminoimidazoline phenyl ketone...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 233/50 (2006.01) A61K 31/4168 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2427900

This invention relates to compounds which are generally prostaglandins I2 (IP) receptor modulators, particularly IP receptor antagonists, and which are represented by the general formula (I) wherein A, R1 and R2 are defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, a process for the preparation of such compounds and their use for treating diseases associated with pain, inflammation, urinary tract disease states, respiratory disease states, edema formation, or hypotensive vascular diseases.

L'invention concerne des composés qui sont généralement des modulateurs de récepteurs de la prostaglandine I ¿2? (IP) et qui sont généralement représentés par la formule générale (I). Dans cette dernière, A, R?1¿ et R?2¿ sont tels que définis dans la spécification. En outre, l'invention a pour objet des isomères individuels, des mélanges racémiques et non racémiques d'isomères et des sels ou des solvates de ces derniers pharmaceutiquement acceptables.L'invention concerne aussi des compositions pharmaceutiques renfermant ces composés, un procédé de préparation de ces composés et leur utilisation pour traiter des maladies associées à la douleur, l'inflammation, les maladies de l'appareil urinaire, des états de maladies respiratoires, la formation d'oedèmes, ou les maladies vasculaires d'hypotension.

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