Macrocyclic serine protease inhibitors

Details Macrocyclic serine protease inhibitors Macrocyclic serine protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/407 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2712971

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula (I), pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

L'invention concerne des composés inhibiteurs de sérine protéase macrocycliques, par exemple, représentés par la formule I, des compositions pharmaceutiques comprenant lesdits composés, ainsi que leurs méthodes de préparation. L'invention concerne également leurs méthodes d'utilisation pour le traitement d'une infection par le VHC chez un hôte en attente d'un tel traitement.

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