Immunomodulating compositions, processes for their...

Details Immunomodulating compositions, processes for their... Immunomodulating compositions, processes for their...

C - Chemistry, Metallurgy

12

N

C12N 5/16 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2494675

The present invention discloses compositions and methods for antigen-specific suppression of immune responses, including primed immune responses. In particular, the invention discloses antigen-presenting cells, especially dendritic cells, whose level and or functional activity of CD40, or its equivalent, is impaired, abrogated or otherwise reduced, and their use for treating and/or preventing unwanted or deleterious immune responses including those that manifest in autoimmune disease, allergy and transplant rejection.

La présente invention concerne des compositions et des procédés conçus pour une suppression spécifique à l'antigène de réponses immunitaires, comprenant des réponses immunitaires sensibilisées. Cette invention concerne notamment des cellules présentatrices d'antigène, en particulier des cellules dendritiques, dont le niveau et/ou l'activité fonctionnelle de CD40 ou d'un équivalent de celui-ci est altéré, supprimé ou réduit, ainsi que leur utilisation pour traiter et/ou prévenir des réponses immunitaires indésirables ou délétères, telles que celles apparaissant en cas de maladie auto-immune, d'allergie et de rejet de greffon.

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