Galectin 8, 9, 10 and 10sv

Details Galectin 8, 9, 10 and 10sv Galectin 8, 9, 10 and 10sv

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/28 (2006.01) C07K 5/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2268022

The present invention relates to novel galectin 8, 9, 10 and 10SV proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 8, 9, 10 and 10SV proteins. Galectin 8, 9, 10 and 10SV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 8, 9, 10 or 10SV activity. Also provided are diagnostic and therapeutic methods.

La présente invention concerne de nouvelles protéines de galectine 8, 9, 10 et 10SV faisant partie de la superfamille des galectines. L'invention concerne en particulier des molécules d'acide nucléique isolées codant des protéines de galectine humaine 8, 9, 10 et 10SV. L'invention concerne également des polypeptides de galectine 8, 9, 10 et 10SV, ainsi que des vecteurs, des cellules hôtes et des méthodes de recombinaison permettant leur production. L'invention concerne aussi des méthodes de criblage permettant d'identifier des agonistes et antagonistes de l'activité de la galectine 8, 9, 10 et 10SV. L'invention concerne enfin des méthodes diagnostiques et thérapeutiques.

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