C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2579349
The present invention relates to agents capable of treating or preventing an allergic disorder in an animal and a method of screening for these agents. In par5icular, the present invention relates to an isolated nucleic acid molecule comprising (a) an isolated nucleic acid molecule whose expression is modulated in a mammal suffering from or at elevated risk of developing an allergic condition, such that the level of expression of the nucleic acid differs from that in a mammal which is not suffering from or at elevated risk of developing the allergic condition, in which the nucleic acid comprises a sequence selected from the group consisting of sequences identified by probes 243610 at on human chromosome 9q21.13 at locus 138255, 1556097 at on human chromosome 15q25.2 and 242743 at on human chromosome 16p12.1 respectively, or (b) an isolated nucleic acid molecule which is the complement of the nucleic acid of (a), or (c) an isolated nucleic acid molecule which hybridizes under stringent conditions to the nucleic acid of (a) or (b).
L'invention concerne des agents pouvant traiter ou prévenir une affection allergique chez un animal, et une méthode de criblage de ces agents. L'invention porte notamment sur une molécule d'acide nucléique isolée comprenant (a) une molécule d'acide nucléique isolée dont l'expression est modulée chez un animal souffrant d'une affection allergique ou fortement prédisposé à une affection allergique, de façon que le niveau d'expression de l'acide nucléique diffère de celui d'un animal ne souffrant pas d'affection allergique ou fortement prédisposé à une affection allergique, l'acide nucléique comportant une séquence sélectionnée dans le groupe constitué de séquences identifiées par les sondes 243610_at sur le chromosome humain 9q21.13 au niveau du locus 138255, 1556097_at sur le chromosome humain 15q25.2 et 242743_at sur le chromosome humain 16p12 :1 respectivement ; ou (b) une molécule d'acide nucléique isolée qui est le complément de l'acide nucléique de (a) ; ou (c) une molécule d'acide nucléique isolée qui s'hybride dans des conditions stringentes à l'acide nucléique de (a) ou (b).
Bosco Anthony
Devitt Catherine
Holt Patrick
Mckenna Katherine
Sly Peter
Ridout & Maybee Llp
Telethon Institute For Child Health Research
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