A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/335 (2006.01) A61K 31/355 (2006.01) A61K 47/22 (2006.01)
Patent
CA 2276730
An emulsion of .alpha.-tocopherol. stabilized by biocompatible surtactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol tree and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated .alpha.-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of .alpha.- tocopherol.
La présente invention concerne une émulsion d' alpha -tocophérol stabilisée au moyen d'agents tensio-actifs biocompatibles et servant d'excipient pour des médicaments à vocation thérapeutique. Cet excipient, qui est sensiblement exempt d'éthanol, peut être administré aux animaux et à l'homme par les différents voies d'administration. L'émulsion contient également de la vitamine E polyéthylèneglycolée. L' alpha -tocophérol polyéthylèneglycolé inclut des sous-unités polyéthylène glycol qui se fixent au cycle hydroxyl de la vitamine E via un diester d'acide succinique. Cet alpha -tocophérol polyéthylèneglycolé sert d'agent tensio-actif primaire, de stabilisant et de solvant secondaire dans les émulsions d' alpha -tocophérol.
Constantinides Panayiotis P.
Lambert Karel J.
Quay Steven C.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Sonus Pharmaceuticals Inc.
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