C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/15 (2006.01) A61K 38/16 (2006.01) A61K 39/21 (2006.01) A61P 31/12 (2006.01) A61P 37/04 (2006.01) C12N 5/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2658393
The present invention provides isolated HERV polypeptides; and compositions, including immunogenic compositions, comprising a HERV polypeptide. The present invention provides immunogenic compositions comprising a nucleic acid comprising a nucleotide sequence encoding a HERV polypeptide. The immunogenic compositions are useful for stimulating a T cell immune response to a lentiviral peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers in which HERV polypeptides are expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a HERV polypeptide.
La présente invention concerne des polypeptides rétroviraux endogènes humains (RVEH) isolés ainsi que des compositions, incluant des compositions immunogènes, qui contiennent un polypeptide RVEH. La présente invention concerne des compositions immunogènes contenant un acide nucléique qui comporte une séquence nucléotidique codant pour un polypeptide RVEH. Les compositions immunogènes se révèlent utiles pour stimuler une réponse immune des lymphocytes T à un peptide lentiviral. La présente invention concerne en outre des procédés permettant de stimuler chez un individu une réponse immune à une cellule infectée par un rétrovirus ou par un lentivirus. La présente invention concerne également des procédés permettant de traiter des cancers associés à l'expression de polypeptides RVEH. L'invention concerne encore des procédés permettant de traiter des troubles qui impliquent une réduction de la réponse immune à un polypeptide RVEH.
Agrawal Ashish
Garrison Keith
Hecht Frederick M.
Jones R. Bradley
Lenz Jack
Albert Einstein College Of Medicine Of Yeshiva University
Fetherstonhaugh & Co.
Jones R. Bradley
Ostrowski Mario
Rakoff-Nahoum Seth
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