Induction of immune response against tetanus toxin through...

A - Human Necessities – 61 – K

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A61K 39/08 (2006.01) A61K 39/39 (2006.01) C07K 14/33 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2110687

2110687 9221374 PCTABS00017 A method of inducing an immune response to a tetanus toxin in an animal which comprises administering to the animal mycobacteria transformed with at least one DNA sequence which encodes a protein or polypeptide which elicits antibodies against tetanus toxin or a fragment or derivative thereof. In one embodiment, the immune response to tetanus toxin is induced by administering to an animal a vaccine including BCG which have been transformed with an expression vector DNA sequence which encodes Fragment C of tetanus toxin.

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