Diagnosis and treatment of malignant neoplasms

Details Diagnosis and treatment of malignant neoplasms Diagnosis and treatment of malignant neoplasms

C - Chemistry, Metallurgy

12

N

C12N 9/04 (2006.01) A61K 31/7088 (2006.01) A61K 38/44 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/40 (2006.01) C12N 5/12 (2006.01) C12N 9/02 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2447367

The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta- hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH- specific immune response are also within the invention.

L'invention concerne un procédé destiné à réaliser un diagnostic et à inhiber la croissance d'une tumeur maligne chez un mammifère, consistant à mettre en contact une cellule ou un fluide corporel du mammifère et un anticorps qui se lie à un polypeptide humain aspartyl (asparaginyl) bêta-hydroxylase (HAAH). Elle concerne aussi des procédés d'immunisation destinés à produire un réponse immunospécifique au polypeptide HAAH.

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