Neisseria meningitidis serogroup b glycoconjugates and...

A - Human Necessities – 61 – K

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Details

A61K 39/385 (2006.01) A61K 39/095 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2264735

The present invention pertains generally to novel Neisseria meningitidis serogroup B glycoconjugates. More particularly, the invention pertains to glycoconjugates formed from a Neisseria meningitidis serogroup B capsular oligosaccharide derivative (MenB OS derivative) in which sialic acid residue N-acetyl groups are replaced with N-acyl groups. The invention also pertains to vaccine formulations containing the glycoconjugates, methods of making the vaccine formulations, and methods of using the vaccine formulations to treat or prevent Neisseria meningitidis serogroup B or E. coli K1 disease in a mammalian subject.

La présente invention concerne en général de nouveaux glycoconjugués du groupe sérologique B de Neisseria meningitidis, et plus particulièrement des glycoconjugués obtenus d'un dérivé d'oligosaccharide capsulaire du groupe sérologique B de Neisseria meningitidis (dérivé MenB OS) dans lequel des groupes N-acétylé des restes d'acide sialique sont remplacés par des groupes N-acylé. Cette invention concerne également des formulations de vaccins contenant les glycoconjugués, leurs procédés de fabrication et d'utilisation, ces formulations étant utiles dans le traitement ou la prévention des pathologies du groupe sérologique B de Neisseria meningitidis ou de E.coli K1 affectant un sujet mammalien.

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