Soluble guanylate cyclase activators

Details Soluble guanylate cyclase activators Soluble guanylate cyclase activators

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/519 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2743864

Compounds of Formula I are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the Formula I.

La présente invention concerne des composés de Formule I qui sont capables de moduler la production par le corps de guanosine-monophosphate cyclique (« GMPc ») et sont généralement adaptés pour la thérapie et la prophylaxie de maladies qui sont associées à un équilibre perturbé du GMPc. Linvention concerne en outre des procédés pour préparer des composés de formule I, leur utilisation pour la thérapie et la prophylaxie des maladies mentionnées ci-dessus et pour préparer des agents pharmaceutiques à cette fin, et des préparations pharmaceutiques qui comprennent des composés de formule I.

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