Blood-brain barrier targeting antibodies

Details Blood-brain barrier targeting antibodies Blood-brain barrier targeting antibodies

C - Chemistry, Metallurgy

07

K

C07K 14/05 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2653444

This invention provides antibodies that bind brain endothelial cell receptors resulting in endocytosis/transcytosis of the receptor and bound ligands. In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the library against cultured cell monolayers. The invention further allows for identifying endothelial cell receptors that bind the antibody thereby providing target receptors against which to isolate further cognate ligands and their associated transport systems and by which to identify transcytosis transporters targeted by the antibodies.

La présente invention concerne des anticorps qui se lient aux récepteurs des cellules de l'endothélium cérébral, permettant ainsi l'endocytose/la transcytose du récepteur et des ligands liés. Dans certains modes de réalisation, le ligand comprend l'anticorps en combinaison avec un composé pharmaceutiquement actif et l'anticorps dirige la délivrance de ce composé à travers la barrière hémato-encéphalique (BHE). L'invention concerne également des procédés d'identification d'anticorps spécifiques aux cellules endothéliales par un panning de la bibliothèque contre des monocouches de cellules cultivées. L'invention permet en outre d'identifier des récepteurs des cellules endothéliales qui se lient à l'anticorps, constituant ainsi des récepteurs cibles par rapport auxquels d'autres ligands apparentés et leurs systèmes de transport associés peuvent être isolés et qui permettent d'identifier des transporteurs de transcytose ciblés par les anticorps.

Affiliated with

Also associated with

Rating

Blood-brain barrier targeting antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Blood-brain barrier targeting antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Blood-brain barrier targeting antibodies will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1803256