Substituted 1,5-naphthyridine azolidinones as cdk inhibitors

Details Substituted 1,5-naphthyridine azolidinones as cdk inhibitors Substituted 1,5-naphthyridine azolidinones as cdk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2602757

The present invention provides novel, substituted 1,5-naphthyridine azolinones of formula (I) which inhibit Cdkl and are selective against Cdk2 and Cdk4. These compounds and their pharmaceutically acceptable salts have antiproliferative activity and are useful as anti-cancer agents.

La présente invention concerne de nouvelles 1,5-naphtyridineazolidinones substituées de formule (I) qui inhibent CdkI et sont sélectives vis-à-vis de Cdk2 et Cdk4. Ces composés et leurs sels de qualité pharmaceutique présentent une activité antiproliférative et peuvent être employés en tant qu'agents anticancéreux.

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