Amyloid beta receptor and uses thereof

Details Amyloid beta receptor and uses thereof Amyloid beta receptor and uses thereof

G - Physics

01

N

G01N 33/68 (2006.01) A61K 31/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2617104

The present invention relates to the identification that soluble assemblies of amyloid .beta. function as a NMDA receptor antagonist. The present invention also provides methods and compositions for the detection and treatment of neurodegenerative and cognitive disorders and screening methods to identify agents that modulate the antagonistic effect of soluble assemblies of amyloid .beta. on NMDA receptor function.

L'invention porte sur une découverte selon laquelle des compositions solubles d'amyloïde ß fonctionnent en tant qu'antagoniste du récepteur NMDA. L'invention porte également sur des méthodes et compositions servant à la détection et au traitement de troubles neurodégénératifs et cognitifs, et sur des méthodes de criblage permettant d'identifier des agents modulant l'effet antagoniste de compositions solubles d'amyloïde ß sur le fonctionnement du récepteur NMDA.

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