Dibenzyl amine derivatives as cetp inhibitors

Details Dibenzyl amine derivatives as cetp inhibitors Dibenzyl amine derivatives as cetp inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/41 (2006.01) A61K 31/454 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) C07D 257/06 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2645291

Dibenzyl amine compounds and derivatives, of Formula (I), pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

La présente invention concerne des dibenzylamines et leurs dérivés de Formule (I), des compositions pharmaceutiques contenant de tels composés et l'application de tels composés à l'augmentation de certaines teneurs plasmatiques en lipides, y compris la lipoprotéine cholestérol haute densité, et à la diminution de certaines autres teneurs plasmatiques en lipides, par exemple la LDL cholestérol et les triglycérides, et ainsi au traitement de maladies exacerbées par des teneurs faibles en HDL cholestérol et/ou des teneurs fortes en LDL cholestérol et en triglycérides, par exemple l'athérosclérose et les maladies cardiovasculaires chez certains mammifères, y compris chez l'homme.

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