Pyrido[2,3-d]pyrimidine derivatives as phosphodiesterase...

Details Pyrido[2,3-d]pyrimidine derivatives as phosphodiesterase... Pyrido[2,3-d]pyrimidine derivatives as phosphodiesterase...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2132297

The present invention relates to optionally substituted pyrido(2,3-d]- pyrimidine-2,4(1H,3H)-diones or optionally substituted pyrido[2,3-d]-pyrimidine-2(1H,3H)-ones, i.e., compounds of Formula (I) wherein: Y is -CH2- or -C(O)-; R1 is hydrogen or -(CH2)n; R7, wherein: R7 is aryl or heteroaryl, and n is 1 or 2, provided that when Y is -C(O)-, R7 is heteroaryl; and R2, R3, R4, R5 and R6 are hydrogen, or one is selected from lower alkyl, halo, carboxy, methoxycarbonyl, carbamoyl, methylcarbamoyl, di-methylcarbamoyl, methylcarbonyl, methylthio, methylsulfinyl, methylsulfonyl, hydroxymethyl, amino, trifluoromethyl; cyano or nitro; or R2, R3, R4 and R5 are independently selected from hydrogen, lower alkyl, nitro, chloro, fluoro, methoxycarbonyl or methylcarbonyl, provided that at least one is hydrogen, and R6 is hydrogen; or a pharmaceutically acceptable ester, ether, N-oxide or salt thereof.

Affiliated with

Also associated with

Rating

Pyrido[2,3-d]pyrimidine derivatives as phosphodiesterase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrido[2,3-d]pyrimidine derivatives as phosphodiesterase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrido[2,3-d]pyrimidine derivatives as phosphodiesterase... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1804830