Methods for detecting major adverse cardiovascular and...

Details Methods for detecting major adverse cardiovascular and... Methods for detecting major adverse cardiovascular and...

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2702268

The present teachings relate to a method of assessing the probability of a major adverse cardiovascular or cerebrovascular event in a human The method can include measuring a concentration, in a blood- based sample of a human, of a set of analytes, for example, alpha-fetoprotein, cancer antigen 125, glutathione S- transferase, and tissue factor The method also can include determining a MACCE index for the set of analytes and identifying the human as having an increased likelihood of a major adverse cardiovascular or cerebrovascular event if the MACCE index is greater than zero, or a decreased likelihood of a mayor adverse cardiovascular or cerebrovascular event if the MACCE index is less than or equal to zero.

L'invention concerne un procédé d'estimation de la probabilité d'un événement cardiovasculaire ou cérébrovasculaire préjudiciable majeur chez un être humain. Le procédé peut comprendre la mesure d'une concentration, dans un échantillon à base de sang d'un être humain, d'un jeu d'analytes, par exemple d'alpha-fétoprotéine, d'antigène 125 du cancer, de glutathione S-transférase et d'un facteur de tissu. Le procédé peut également comprendre la détermination d'un indice MACCE pour le jeu d'analytes et l'identification de l'être humain comme présentant une probabilité accrue de subir un événement cardiovasculaire ou cérébrovasculaire préjudiciable majeur si l'indice MACCE est supérieur à zéro, ou bien une probabilité diminuée de subir un événement cardiovasculaire ou cérébrovasculaire préjudiciable majeur si l'indice MACCE est inférieur ou égal à zéro.

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