A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 31/198 (2006.01)
Patent
CA 2441111
The present invention concerns a method for selectively targeting a medicinally-useful agent into cells in which a phospholipid scramblase (PLS) transport system is activated. The method comprises administering the agent, being a PLS-dependent transported compound (PDTC) to the cells, thereby causing selective transport of the agent into the cells. Examples of the cells are apoptotic cells, activated cells and injured cells. Also disclosed are pharmaceutical compositions for use by the method.
La présente invention porte sur un procédé de ciblage sélectif d'un agent utile en médecine sur des cellules dans lesquelles un système de transport scramblase phospholipidique (PLS) est activé. Le procédé consiste à administrer l'agent, qui est un composé transporté dépendant de PLS (PDTC) dans les cellules, ce qui génère le transport sélectif de l'agent dans les cellules. Ces cellules sont par exemple des cellules apoptiques, des cellules activées et des cellules lésées. L'invention porte également sur des compositions pharmaceutiques destinées à être utilisées par ce procédé.
Ebner Sharon
Shirvan Anat
Ziv Ilan
Nst Neurosurvival Technologies Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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