Selective inhibitors of histone deacetylase

Details Selective inhibitors of histone deacetylase Selective inhibitors of histone deacetylase

C - Chemistry, Metallurgy

07

D

C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 235/10 (2006.01) C07D 235/12 (2006.01) C07D 235/14 (2006.01)

Patent

CA 2721218

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.

Cette invention concerne des composés et des compositions pharmaceutiques les contenant, qui inhibent l'activité histone désacétylase 8 (HDAC8). Des procédés d'utilisation de ces inhibiteurs de HDAC8, seuls ou en combinaison avec d'autres composés, sont également décrits pour traiter des maladies ou des affections susceptibles de bénéficier d'une inhibition de l'activité HDAC8.

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