N-alkyl-azacycloalkyl nmda/nr2b antagonists

Details N-alkyl-azacycloalkyl nmda/nr2b antagonists N-alkyl-azacycloalkyl nmda/nr2b antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) A61P 31/18 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2603876

Compounds represented by Formula (I): and/or pharmaceutically acceptable salts, individual enantiomers and stereoisomers thereof, are effective as NMDA/NR2B antagonists useful for treating conditions such as pain, Parkinson~s disease, Alzheimer~s disease, epilepsy, depression, anxiety, ischemic brain injury including stroke.

La présente invention concerne des composés représentés par la formule (I) et/ou des sels, des énantiomères individuels et des stéréoisomères de ceux-ci, acceptables d'un point de vue pharmaceutique, qui sont efficaces comme antagonistes de NMDA/NR2B, utilisés pour traiter des pathologies comme la douleur, la maladie de Parkinson, la maladie d'Alzheimer, l'épilepsie, la dépression, l'anxiété et les lésions cérébrales d'origine ischémique, par exemple l'accident vasculaire cérébral.

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