Gm-negative ehv-mutants without heterologous elements

Details Gm-negative ehv-mutants without heterologous elements Gm-negative ehv-mutants without heterologous elements

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 39/12 (2006.01) A61K 39/125 (2006.01) A61K 39/29 (2006.01) C07K 14/03 (2006.01) C07K 14/18 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/34 (2006.01)

Patent

CA 2493406

The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous elements. Further aspects of the invention relate to pharmaceutical compositions comprising said viruses, uses thereof, and methods for the prophylaxis and treatment of EHV infections. The invention also relates to pharmaceutical compositions comprising the combination of EHV-1 and EHV-4 viruses wherein the gene encoding the protein gM is absent and which is free of heterologous elements.

L'invention concerne le domaine de la santé animale, et en particulier les virus de l'herpès équin (VHE) dans lesquels le gène codant pour la protéine gM est absent et dépourvu d'éléments hétérologues. D'autres aspects de l'invention concernent des compositions pharmaceutiques comprenant ces virus, des applications de celles-ci et des méthodes visant à prévenir et à traiter des infections par le VHE. L'invention concerne aussi des compositions pharmaceutiques qui comprennent les virus VHE-1 et VHE-4 combinés, dans lesquels le gène qui code pour la protéine gM est absent et dépourvu d'éléments hétérologues.

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