A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2690244
Described herein are MetAP-2 inhibitors and compositions and formulations thereof, and more particularly compositions and formulations of MetAP-2 inhibitors wherein the MetAP-2 inhibitor is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety. The present invention also relates to compositions and formulations comprising MetAP-2 inhibitors for oral administration or administration via routes such as topical or ocular administration. The present invention also provides methods to treat conditions associated with or related to the over-expression or over-activity of MetAP-2 by administering the compositions and formulations comprising MetAP-2 inhibitors as disclosed herein.
L'invention concerne des inhibiteurs de MetAP-2 et des compositions et formulations de ces derniers, et en particulier des compositions et formulations d'inhibiteurs de MetAP-2 dans lesquelles l'inhibiteur de MetAP-2 est associé à un copolymère séquencé renfermant un fragment polymère hydrophile et un fragment polymère hydrophobe. L'invention se rapporte également à des compositions et formulations renfermant des inhibiteurs de MetAP-2 qui sont destinées à l'administration orale ou à l'administration topique ou oculaire, par exemple. L'invention porte aussi sur des procédés qui permettent de traiter des états associés ou liés à la surexpression ou à la suractivité de MetAP-2 par l'administration des compositions et formulations précitées.
Benny-Ratsaby Ofra
Folkman Judah
Children's Medical Center Corporation
Gowling Lafleur Henderson Llp
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