Thiazolylphenylcarbamoylmethyl amide derivative

Details Thiazolylphenylcarbamoylmethyl amide derivative Thiazolylphenylcarbamoylmethyl amide derivative

C - Chemistry, Metallurgy

07

D

C07D 277/40 (2006.01) A61K 8/42 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/433 (2006.01) A61K 31/439 (2006.01) A61K 31/454 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/536 (2006.01) A61K 31/5415 (2006.01) A61P 31/22 (2006.01) C07D 277/62 (2006.01) C07D 277/64 (2006.01) C07D 277/74 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2428184

The invention relates to a novel amide derivative which is an N-({[4-(substituted thiazol-4--yl)phenyl]carbamoyl}methyl)amide derivative having a characteristic in that an aryl or heteroaryl group as an aromatic ring group is directly substituted on the N atom of amido group. Since said amide derivative has excellent anti-herpesvirus action, it is useful as medicaments and antiviral agents, particularly as preventive or therapeutic agents for various diseases accompanied by Herpesviridae virus infections, illustratively, varicella (chickenpox) accompanied by varicella zoster virus infection, shingles accompanied by the recurrent infection of latent varicella zoster virus, labial herpes and herpes encephalitis accompanied by HSV-1 infection, genital herpes accompanied by HSV-2 and the like various herpesvirus infections.

Cette invention concerne des dérivés amides N({4-(substitué thiazol-4-yl)phényle] carbomoyle}méthyle), l'atome N du groupe amido porte un substituant aryle ou hétéroaryle (c'est-à-dire un groupe à cycle aromatique) attaché directement à lui. Compte tenu de leur excellente activité contre les virus de l'herpès, ces dérivés amides conviennent bien comme médicaments et agents antiviraux, en particulier à titre préventif et prophylactique pour diverses maladies dues à une infection par des virus herpétiques, plus précisément pour diverses infections provoquées par de tels virus telle que la pustullose varioliforme due à une infection par le virus varicelle-zona, le zona provoqué par une infection récurrente due au virus varicelle-zona, l'herpès de la lèvre et l'encéphalite herpétique dues à une infection par l'herpès simplex virus type 1 et l'herpès génital du à une infection par l'herpès simplex virus type 2.

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