Crystal structure of apopain and uses thereof

Details Crystal structure of apopain and uses thereof Crystal structure of apopain and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) C07K 5/113 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247068

The invention relates to crystallized apopain, the use of that structure to solve the structure of apopain homologues and other crystal forms of apopain, mutants and co-complexes of apopain, and the use of the apopain structure and that of its homologues, mutants, and co-complexes to design modulators of apopain.

L'invention porte sur l'apopaïne cristallisée, sur l'utilisation de cette structure cristallisée pour obtenir des homologues d'apopaïne et d'autres formes cristallines d'apopaïne, de mutants et de co-complexes d'apopaïne, et enfin sur l'utilisation de la structure cristallisée de l'apopaïne et de celle de ses homologues, mutants et co-complexes pour concevoir des modulateurs de l'apopaïne.

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