Use of catecholic butane derivatives in cancer therapy

Details Use of catecholic butane derivatives in cancer therapy Use of catecholic butane derivatives in cancer therapy

A - Human Necessities

61

K

A61K 31/05 (2006.01) A61P 35/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2742986

The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes can serve as dual kinase inhibitors for purposes of methods described herein. Subjects can be further treated by co- administering an EGFR inhibitor. The present application also relates to analyzing a sample with respect to levels of IGF- IR and EGFR and comparing levels of IGF-IR and EGFR to a control. Patients can be selected for treatment with a catecholic butane based on the assessment; optionally, patients can be further treated with an EGFR inhibitor, an IGF-IR inhibitor, or both.

La présente invention concerne des compositions et des procédés pour traiter un trouble prolifératif par administration à un sujet dune composition pharmaceutique dun double inhibiteur de kinase. Les butanes catécholiques peuvent servir de doubles inhibiteurs de kinase pour les procédés présentement décrits. Des sujets peuvent en outre être traités par co-administration dun inhibiteur dEGFR. La présente invention concerne en outre lanalyse dun échantillon pour déterminer les taux dIGF-IR et dEGFR et comparer les taux dIGF-IR et dEGFR à un témoin. Des patients peuvent être sélectionnés pour le traitement avec un butane catécholique sur la base de lévaluation ; éventuellement, des patients peuvent en outre être traités avec un inhibiteur dEGFR, un inhibiteur dIGF-IR, ou les deux.

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