A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/00 (2006.01) A61K 31/506 (2006.01)
Patent
CA 2477111
The present invention relates to a method for treating CNS disorders, more particularly selected from the group consisting of depression, schizophrenia, anxiety, migraine, memory loss, pain and neurodegenerative diseases, comprising administering a compound capable of depleting mast cells to a human in need of such treatment. Such compounds can be chosen from tyrosine kinase inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.
L'invention concerne une méthode de traitement de troubles du SNC, plus particulièrement ceux sélectionnés parmi le groupe comprenant dépression, schizophrénie, anxiété, migraine, perte de mémoire, douleur et maladies neurodégénératives, consistant à administrer un composé pouvant réduire le nombre de mastocytes chez un humain nécessitant un tel traitement. Ces composés peuvent être choisis parmi des inhibiteurs de tyrosine kinase et plus particulièrement parmi des inhibiteurs c-kit puissants, sélectifs et non toxiques. Cet inhibiteur est, de préférence, incapable de favoriser la mort de cellules dépendantes d'IL-3 cultivées en présence d'IL-3.
Kinet Jean-Pierre
Moussy Alain
Ab Science
Smart & Biggar
LandOfFree
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