C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/12 (2006.01) C07K 14/18 (2006.01) C12N 7/01 (2006.01) C12N 15/40 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2337905
The present invention provides a recombinant alphavirus comprising at least one epiviral nonalphaviral sequence, which (i) is present in the E1, E2 or E3 glycoprotein as an insertion or as a replacement of one or more amino acid residues and which (ii) directly and selectively binds to a region on a target cell-specific, surface receptor. The present invention also provides the nucleic acids related to said alphavirus, and methods to treat cancer in a mammal using the alphavirus and related nucleic acids.
L'invention concerne un alphavirus recombinant contenant au moins une séquence non alphavirale épivirale qui (i) est présente dans la glycoprotéine E1, E2 ou E3 comme insertion ou en remplacement d'un ou plusieurs résidus d'acide aminé et qui (ii) se lie directement et sélectivement à une région sur un récepteur de surface cible qui est spécifique de cellule. L'invention concerne également les acides nucléiques liés à cet alphavirus et des méthodes de traitement du cancer chez un mammifère au moyen de cet alphavirus et des acides nucléiques correspondants.
Dropulic Boro
Dropulic Lesia
Hardwick J. Marie
Fetherstonhaugh & Co.
Johns Hopkins University School Of Medicine
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