Stabilized hbc chimer particles as therapeutic vaccine for...

Details Stabilized hbc chimer particles as therapeutic vaccine for... Stabilized hbc chimer particles as therapeutic vaccine for...

A - Human Necessities

61

K

A61K 39/29 (2006.01) A61K 39/385 (2006.01) A61P 31/20 (2006.01)

Patent

CA 2516640

A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protein (HBc) that is engineered for both enhanced stability of self-assembled particles and the substantial absence of nucleic acid binding by those particles. The chimeric protein molecule can include one or more immunogenic epitopes peptide-bonded to one or more of the N-terminus, the immunogenic loop or the C-terminus of HBc. The enhanced stability of self-assembled particles is obtained by the presence of at least one heterologous cysteine residue near one or both of the amino-terminus and carboxy-terminus of the chimer molecule.

La présente invention a trait à un procédé de traitement de l'hépatite B chronique comprenant l'administration d'une quantité de vaccin de stimulation de lymphocytes T à un patient. Le vaccin comporte une quantité immunogène de protéine (HBc) nucléocapsidique (noyau) du virus chimérique de l'hépatite B à terminal carboxy tronqué qui est génétiquement modifié pour une stabilité améliorée de particules auto-assemblées et de l'absence notable d'acide nucléique de liaison aux dites particules. La molécule de protéine chimérique peut comprendre un ou des épitopes immunogènes à liaison peptidique au N-terminal et/ou à la boucle immunogène et/ ou au C-terminal de HBc. La stabilité améliorée des particules auto-assemblées est obtenue par la présence d'au moins un résidu de cystéine hétérologue à proximité du N-terminal et/ou du C-terminal de la molécules chimérique.

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